Optical Applications in Biomedicine

In vivo biological imaging using single-photon and two-photon fluorescence microscopy based on confocal microscopy systems, and related physical issues

Spectrally-resolved and time-resolved fluorescence detection for biological applications

Early cancer diagnosis and photodynamic therapy

Application of optical probes, fluorescent nanoparticles, and bio-targeted nanomaterials in biomedical research

2011 Second-Prize Teaching Scholarship, College of Information Science, Fudan University

2012 Third-Prize Teaching Scholarship, College of Information Science, Fudan University

Sept. 2002 – Jun. 2007: Ph.D., Department of Optical Science and Engineering, School of Information Science and Technology, Fudan University

Jun. 2001 – Aug. 2001: “Junzheng Scholar” for Cross-Strait Exchange, Department of Physics, National Tsing Hua University, Hsinchu, Taiwan

Sept. 1998 – Jun. 2002: B.Sc., Department of Physics, Fudan University

Aug. 2003 – Aug. 2004: Visiting Scholar, Department of Physics, Eastern Michigan University, USA

Undergraduate courses: University Physics; Modern Physics; Biophotonics in Medicine

Postgraduate courses: Laser Spectroscopy; Biophotonics

X. Pan, X. Liang, L. Yao, X. Wang, Y. Jing, J. Ma, Y. Fei, L. Chen, L. Mi* , “Study of the Photodynamic Activity of N-Doped TiO 2 Nanoparticles Conjugated with Aluminum Phthalocyanine”, Nanomaterials , 7, 338 (2017).

M . Wang, F. Tang, X. Pan, L. Yao, X. Wang, Y. Jing, J. Ma, G.g Wang, L . Mi*, " Rapid Diagnosis and Intraoperative Margin Assessment of Human Lung Cancer with Fluorescence Lifetime Imaging Microscopy ", BBA Clinical , 8, 7-13 (2017)

M. Wang, F. Long, F. Tang, Y. Jing, X. Wang, L. Yao, J. Ma, Y. Fei, L. Chen, G. Wang, L. Mi * ,"Autofluorescence Imaging and Spectroscopy of Human Lung Cancer", Appl. Sci. 7 (2017) 32.

J. Xie, X. Pan, M. Wang, J. Ma, Y. Fei, P.-N. Wang, L. Mi * ," The role of surface modification for TiO 2 nanoparticles in cancer cells", Colloid. Surface. B 143 (2016) 148.

Y. Wang, C. Song, M. Wang, Y. Xie, L. Mi * , G. Wang,"Rapid, Label-Free, and Highly Sensitive Detection of Cervical Cancer With Fluorescence Lifetime Imaging Microscopy", IEEE J. Sel. Top. Quant. 22 (2016) 6801307.

J. Xie, X. Pan, M. Wang, L. Yao, X. Liang, J. Ma, Y. Fei, P.-N. Wang, L. Mi * ,"Targeting and Photodynamic Killing of Cancer Cell by Nitrogen-Doped Titanium Dioxide Coupled with Folic Acid", Nanomaterials 6 (2016) 113.

X. Pan, J. Xie, Z. Li, M. Chen, M. Wang, P.-N. Wang, L. Chen, L. Mi * ,"Enhancement of the photokilling effect of aluminum phthalocyanine in photodynamic therapy by conjugating with nitrogen-doped TiO 2 nanoparticles", Colloid. Surface. B 130 (2015) 292.

L. Mi , A. Goryaynov, A. Lindquist, M. Rexach, W. Yang,"Quantifying Nucleoporin Stoichiometry Inside Single Nuclear Pore Complexes In vivo", Sci. Rep. 5 (2015) 9372.

X. Pan, Z. Li, T. Wang, J. Xie, P.-N. Wang, J.-Y. Chen, L. Chen, L. Mi * ,"Study of Polycation-Capped Mn:ZnSe Quantum Dots as a Novel Fluorescent Probe for Living Cells", J. Fluoresc. 24 (2014) 767.

Z. Li, X. Pan, T. Wang, P.-N. Wang, J.-Y. Chen, L. Mi * ,"Comparison of the killing effects between nitrogen-doped and pure TiO 2 on HeLa cells with visible light irradiation", Nanoscale Res. Lett. 8 (2013) 96.

Z. Li, L. Mi *, P.-N. Wang, J.-Y. Chen,"Study on the visible-light-induced photokilling effect of nitrogen-doped TiO 2 nanoparticles on cancer cells", Nanoscale Res. Lett. 6 (2011)

R. Xiong, Z. Li, L. Mi * , P.-N. Wang, J.-Y. Chen, L. Wang, W.-L. Yang,"Study on the Intracellular Fate of Tat Peptide-Conjugated Quantum Dots by Spectroscopic Investigation", J. Fluoresc. 20 (2010) 551.

L. Mi , R. Xiong, Y. Zhang, Z. Li, W. Yang, J.-Y. Chen, P.-N. Wang,"Microscopic observation of the intercellular transport of CdTe quantum dots through tunneling-nanotubes", J. Biomaterials Nanobiotech. 2 (2011) 172.

L. Mi , Y. Zhang, P.-N. Wang,"First-principles study of the hydrogen doping influence on the geometric and electronic structures of N-doped TiO 2 ", Chem. Phys. Lett. 458 (2008) 341.

L. Mi , P. Xu, P.-N. Wang,"Experimental study on the bandgap narrowings of TiO 2 films calcined under N 2 or NH 3 atmosphere", Appl. Surf. Sci. 255 (2008) 2574.

L. Mi , P. Xu, H. Shen, P.-N. Wang,"Recovery of visible-light photocatalytic efficiency of N-doped TiO 2 nanoparticulate films", J. Photoch. Photobio. A 193 (2008) 222.

L. Mi , P. Xu, H. Shen, P.-N. Wang, W. Shen,"First-principles calculation of N : H codoping effect on energy gap narrowing of TiO 2 ", Appl. Phys. Lett. 90 (2007)

L. Mi , H. Ling, W. Shen,"Some complementary scratch resistance characterization methods", JCT Research 3 (2006) 249.

L. Mi , P. Xu, P.-N. Wang,"Temperature determination of N 2 discharge plasma by computational simulation of its emission spectra", J. Phys. D 38 (2005) 3885.

C. Zhu, X. Zhu, J. P. Landry, Z. Cui, Q. Li, Y. Dang, L. Mi , F. Zheng, Y. Fei,"Developing an Efficient and General Strategy for Immobilization of Small Molecules onto Microarrays Using Isocyanate Chemistry", Sensors 16 (2016) 378.

C. Zhu, R. Chen, Y. Zhu, X. Wang, X. Zhu, L. Mi , F. Zheng, Y. Fei,"Calibration of oblique-incidence reflectivity difference for label-free detection of a molecular layer", Appl. Opt. 55 (2016) 9459.

H. Meng, J.-Y. Chen, L. Mi , P.-N. Wang, M.-Y. Ge, Y. Yue, N. Dai,"Conjugates of folic acids with BSA-coated quantum dots for cancer cell targeting and imaging by single-photon and two-photon excitation", J. Biol. Inorg. Chem. 16 (2011) 117.

Y. Zhang, L. Mi , J.-Y. Chen, P.-N. Wang,"The environmental influence on the photoluminescence behavior of thiol-capped CdTe quantum dots in living cells", Biomed. Mater. 4 (2009)