Development and Application of High-Throughput Optical Biosensing Devices

Development of label-free high-throughput biomolecular interaction detection instruments based on ellipsometry

Development of high-sensitivity high-throughput biomolecular interaction detection instruments based on surface plasmons and phase detection

High-throughput drug screening using small molecule microarrays

Omics research using biochips

Dean’s Award, 2021

Nature paper published in 2019 selected as one of the Top Ten Papers of the Year, 2019

PhD graduate Zhu Chenggang received “Fudan University Outstanding Graduate”, 2019

1996–2000: B.Sc., Department of Physics, Beijing Normal University

2000–2006: Ph.D., Institute of Physics, Chinese Academy of Sciences

2004–2006: Visiting Scholar, Department of Physics, University of California, Davis, USA

2006–2012: Postdoctoral Fellow, Department of Physics, University of California, Davis, USA

2012–present: Department of Optical Science and Engineering, School of Information Science and Technology, Fudan University

Optics (Compulsory Undergraduate Course)

Polarisation Optics (Elective Undergraduate Course)

1. 1. Z.Y. Li#, C. Wang#, Z.Y. Wang#, C. G. Zhu#, J. Li, T. Sha, L.X. Ma, C. Gao, Y. Yang, Y.M. Sun, J. Wang, X.L. Sun, C.Q. Lu, M. Difiglia, Y.N. Mei, C. Ding, S. Q. Luo, Y. J. Dang, Y. Ding*, Y. Y. Fei* , B.X. Lu*, Allele-selective Lowering of Mutant HTT Protein by HTT-LC3 Linker Compounds, Nature , 575, 203-209, (2019).

2. B.L. Ge, S. Larson, H. T. Tu, Y. P. Zhao, Y. Y. Fei* , Generalized ellipsometry characterization of Ag nanorod arrays prepared by oblique angle deposition, Nanotechnology , 31, 075075, (2019).

3. H. P. Liu, H. P. Zhang, X. Y. Wu, D. P. Ma, J. H. Wu, L, Wang, Y. Jiang, Y. Y. Fei, C. G. Zhu, R. Tan, P. Jungblut, G. Pei, A. Dorhoi, Q. L. Yan, F. Zhang, R. J. Zheng, S. Y. Liu, H. J. Liang, Z. H. Liu, H. Yang, J. X. Chen, P. Wang, T. Q. Tang, W. X. Peng, Z. S. Hu, Z. Xu, X. C. Huang, J. Wang, H. H. Li, Y. L. Zhou, F. Liu, D. P. Yan, S. H. Kaufmann, C. Chen, Z. Y. Mao*, B. X. Ge*, Nuclear cGAS suppresses DNA repair and promotes tumorigenesis, Nature , 563, 131-136, (2018).

4. Z. H. Li, C. G. Zhu, Z. H. Guo, B. W. Wang, X. Wu*, Y. Y. Fei*, Highly sensitive label-free detection of small molecules with an optofluidic microbubble resonator, Micromachines, 9, 274, (2018).

5. J. W. Hu, R. Chen, C. G. Zhu, B. L. Ge, X. D. Zhu, L. Mi, J. Ma, C. Q. Han, H. Chen*, Y. Y. Fei* , Label-free microarray-based binding affinity constant measurement with modified fluidic arrangement, BioChip. J. 12, 11, (2018).

6. C. G. Zhu, G. L. Ge, R. Chen, X. D. Zhu, L. Mi, J. Ma, X. Wang, F.Y. Zheng, Y. Y. Fei*, Fast focal point correction in prism-coupled total internal reflection scanning imager using an electronically tunable lens, Sensors, 18, 524, (2018).

7. R. Chen, C. G. Zhu, G. L. Ge, X. D. Zhu, Y. S. Sun, L. Mi, J. Ma, X. Wang, Y. Y. Fei*, Detecting signals with direct Fast Fourier Transform for microarray data collection, IEEE Photonic. Tech. L. 29, 2211 (2017).

8. J. J. Wang, C. G. Zhu, D. Song, R. Q. Xia, W. Bo. Yu, Y. J. Dang. Y. Y. Fei , L.Yu, J. X. Wu, Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity, Cell Death Discovery 3, 17034 (2017).

9. C. G. Zhu, Y. Y. Fei* , X. D. Zhu, High-throughput screening based on label-free detection of small molecule microarray, Proc. SPIE 10081, 100810S (February 23, 2017); doi:10.1117/12.2246462.

10. C. G. Zhu, X. D. Zhu, J. P. Landry, Z. M. Cui, Q. F. Li, Y. J. Dang, L Mi, F. Y, Zheng and Y. Y. Fei* , Developing an efficient and general strategy for immobilization of small molecules onto microarrays using isocyanate chemistry, Sensor, 16,378,(2016).

11. C. G. Zhu, R. Chen, Y. Z. Z. Zhu, X. Wang, X. D. Zhu, L. Mi, F. Y. Zheng, Y. Y. Fei*, Calibration of oblique-incidence reflectivity difference (OI-RD) for label-free detection of molecular layer, Appl. Opt. 55, 9459 (2016).

12. X. X. Guo, Y. H. Deng, C. G. Zhu, J. L. Cai, X. D. Zhu, J. P. Landry, F. Y. Zheng, X. J. Cheng, Y. Y. Fei*, Characterization of protein expression levels with label-free detected reverse phase protein arrays, Anal. Biochem. 509, 67 (2016).

13. Y. Y. Fei* , Y. S. Sun, Y. H. Li, H. Yu, K. Lam, J. P. Landry, Z. Luo, N. Baumgarth, X. Chen and X. D. Zhu, Characterization of receptor binding profiles of influenza A viruses using a label-free glycan microarray assay platform, Biomolecules , 5, 1840, (2015).

14. Y. Y. Fei* , J. P. Lanry, Y. H. Li, H. Yu, K. Lam, S. S. Huang, H. A. Chokhawala, X. Chen and X. D. Zhu, An optics-based variable-temperature assay system for characterizing thermodynamics of biomolecular reactions on solid support, Rev. Sci. Instrum . 84, 114102, (2013).